Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry

Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry.

Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional partner of HTLV-1 envelope (Env) proteins. HTLV-1 Env and NRP1 complexes are fo...

High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases

Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.Materials and Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary an...

Incidence of Human T-Lymphotropic Virus Type 1 (HTLV-1) among Blood Donors from Ilam, Iran

Awareness of laboratory students of Mashhad University of Medical Sciences about human T-cell lymphotropic virus type 1 (HTLV-1)

Introduction: HTLV-1 virus is a human retrovirus and it causes several chronic diseases. So far, there is not any vaccine or satisfactory treatment that has been developed for infections caused by this virus. Moreover, the best way to control the infection is prevention and the best way to prevent it is education. Therefore, our study was conducted to investigate the knowledge and attitudes of ...

Evaluating the Frequency of Human T-Lymphotropic Virus Type 1 Infection in Iranian Population

Background: Human T-cell lymphotropic viruses 1 (HTLV1) is endemic in specific regions. We aimed to determine the prevalence of HTLV I infection among blood donors in southeast Iran.   Methods: This cross-sectional study was conducted between April 2005 and March 2015. Sera were collected from blood donors and were tested for the presence of HTLV1 specific antibody using ELISA. Reactive sample...